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Biodegradable Gels of Insulin: Controlled Release of Insulin
Atul J. Shukla Ph.d.
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Biodegradable Gels of Insulin: Controlled Release of Insulin
Atul J. Shukla Ph.d.
The objective of the study was to develop a controlled release dosage form of insulin, which can provide basal concentrations of insulin in diabetic rats for 1 to 2 weeks after a single subcutaneous injection. A biodegradable injectable drug delivery gel was prepared by dissolving a biodegradable polymer, polylactic-co-glycolic acid (PLGA), in biocompatible plasticizer(s), triethyl citrate (TEC) and/or acetyl triethyl citrate (ATEC). Insulin or modified insulin was then loaded into the blank gel to form insulin or modified insulin suspension in the polymer solution. After the insulin-loaded gel was injected subcutaneously, the insulin or modified insulin was released slowly from the depot by a combination of drug diffusion and erosion of the polymer. The formulation prepared with 5% PLGA, ATEC: TEC (3:1) and 4% modified insulin glargine was able to suppress the blood glucose concentrations of the ZDF rats significantly for 10 days after a single subcutaneous injection. The addition of zinc sulfate to the formulations prepared with purified insulin glargine particles further slowed down the drop in blood glucose concentrations.
Medien | Bücher Taschenbuch (Buch mit Softcover und geklebtem Rücken) |
Erscheinungsdatum | 23. April 2010 |
ISBN13 | 9783639217773 |
Verlag | VDM Verlag Dr. Müller |
Seitenanzahl | 132 |
Maße | 225 × 8 × 150 mm · 204 g |
Sprache | Englisch |
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